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DelveInsight’s, “TCR Therapy Pipeline Insight, 2023,” report provides comprehensive insights about 25+ companies and 35+ pipeline drugs in the TCR Therapy pipeline landscape. It covers the TCR Therapy pipeline drug profiles, including TCR Therapy clinical trials and nonclinical stage products. It also covers the TCR Therapy pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. 

In the TCR Therapy pipeline report, a detailed description of the drug is given which includes the mechanism of action of the drug, TCR Therapy clinical trials studies, TCR Therapy NDA approvals (if any), and product development activities comprising the technology, TCR Therapy collaborations, licensing, mergers and acquisition, funding, designations and other product-related details.

Key takeaways from the TCR Therapy Pipeline Report

• Over 25+ TCR Therapy companies are evaluating 35+ TCR Therapy pipeline therapies in various stages of development, and their anticipated acceptance in the TCR Therapy market would significantly increase market revenue.

• The leading TCR Therapy Companies includes T-Cure, BioNTech, TScan therapeutics, Adaptimmune, TCR2 Therapeutics, Immatics N.V., Anocca AB, Gritstone, LION TCR, MediGene AG, Adaptive Biotechnologies, Cell Medica Ltd, Bellicum Pharmaceuticals, Takara Bio, Guangzhou FineImmune Biotechnology, Immatics US, Inc., Lonza Walkersville, Inc., PACT Pharma, Inc., Bluebird Bio, T-knife Therapeutics, GlaxoSmithKline, Eureka Therapeutics, and others.

• Promising TCR Therapy Pipeline Therapies includes GSK3377794, BPX-701, MDG1011, and others.

• The TCR Therapy companies and academics are working to assess challenges and seek opportunities that could influence TCR Therapy R&D. The TCR Therapy pipeline therapies under development are focused on novel approaches to treat/improve TCR Therapy.

To explore more information on the latest breakthroughs in the TCR Therapy Pipeline treatment landscape of the report, click here @ TCR Therapy Pipeline Outlook

TCR Therapy Overview

T-cell receptor (TCR)-based adaptive therapy employs genetically modified lymphocytes that are directed against specific tumor markers. This therapeutic modality requires a structured and integrated process that involves patient screening (e.g., for HLA-A*02:01 and specific tumor targets), leukapheresis, generation of transduced TCR product, lymphodepletion, and infusion of the TCR-based adoptive therapy. The majority of TCR structures are heterodimers comprised of α- and β-chains that are covalently linked via a disulfide bond between the conserved cysteine residues located within the constant region of each chain. Adoptive cell therapy (ACT), which uses genetically engineered human lymphocytes, is increasingly being investigated in patients with hematologic malignancies and solid tumors. The implementation of TCR Therapy will require a shortened time to manufacture TCR products and decreased overall cost associated with the administration of TCR Therapy.

Latest Developmental Activities or News of the TCR Therapy Treatment Landscape

• The TCR-modified T cell product targeting the tumor antigen PRAME (PReferentially expressed Antigen in MElanoma) is being tested in a Phase I/II clinical trial in approximately 92 blood cancer patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) or multiple myeloma (MM).

• In vitro study data showed that BPX-701 demonstrated strong affinity to panels of cancer cells presenting PRAME peptides and low affinity to non-tumor cells, as well as complete elimination of BPX-701 cells in response to rimiducid. It is being investigated in Phase I/II stage of development.

For further information, refer to the detailed TCR Therapy Unmet Needs, TCR Therapy Market Drivers, and TCR Therapy Market Barriers, click here for TCR Therapy Ongoing Clinical Trial Analysis

TCR Therapy Emerging Drugs Profile

GSK3377794: GlaxoSmithKline

Letetresgene autoleucel (GSK3377794) is the first generation of NY-ESO-1 specific T-cell receptor (TCR) engineered T-cells. GSK has exercised the option to obtain an exclusive global license from Adaptimmune for an investigational SPEAR T-cell receptor therapy targeting NY-ESO-1 (GSK3377794). Upon exercise of this option and transition of the programme, GSK has assumed responsibility for all development, manufacturing and commercialization activities for the asset. GSK3377794 has been granted PRIME designation by the European Medicines agency and Breakthrough Therapy Designation by the US Food and Drug Administration. It is currently being evaluated in Phase II clinical trial to treat non-small cell lung cancer.

BPX-701: Bellicum Pharmaceuticals

BPX-701 is a CaspaCIDe®-enabled natural high affinity T cell receptor (TCR) product candidate designed to target malignant cells expressing the preferentially-expressed antigen in melanoma (PRAME). Initial planned indications for BPX-701 development are Refractory or Relapsed Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) with an additional study planned for metastatic uveal melanoma. In vitro study data showed that BPX-701 demonstrated strong affinity to panels of cancer cells presenting PRAME peptides and low affinity to non-tumor cells, as well as complete elimination of BPX-701 cells in response to rimiducid. It is being investigated in Phase I/II stage of development.

MDG1011: Medigene AG

MDG1011 is Medigene’s first proprietary, clinical stage TCR immunotherapy product candidate. The TCR-modified T cell product targeting the tumor antigen PRAME (PReferentially expressed Antigen in MElanoma) is being tested in a Phase I/II clinical trial in approximately 92 blood cancer patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) or multiple myeloma (MM).

TCR Therapy Pipeline Therapeutics Assessment

There are approx. 25+ key companies which are developing therapies for TCR Therapy. The companies which have their TCR Therapy drug candidates in the most advanced stage, i.e. Phase II include, GlaxoSmithKline.

Request a sample and discover the recent advances in TCR Therapy Ongoing Clinical Trial Analysis and Medications, click here @ TCR Therapy Treatment Landscape

Scope of the TCR Therapy Pipeline Report

• Coverage- Global
• TCR Therapy Companies- T-Cure, BioNTech, TScan therapeutics, Adaptimmune, TCR2 Therapeutics, Immatics N.V., Anocca AB, Gritstone, LION TCR, MediGene AG, Adaptive Biotechnologies, Cell Medica Ltd, Bellicum Pharmaceuticals, Takara Bio, Guangzhou FineImmune Biotechnology, Immatics US, Inc., Lonza Walkersville, Inc., PACT Pharma, Inc., Bluebird Bio, T-knife Therapeutics, GlaxoSmithKline, Eureka Therapeutics, and others.
• TCR Therapy Pipeline Therapies- GSK3377794, BPX-701, MDG1011, and others.
• TCR Therapy Pipeline Segmentation: Phases, Mechanism of Action, Route of Administration, Product Type

Dive deep into rich insights for drugs for TCR Therapy Market Drivers and TCR Therapy Market Barriers, click here @ TCR Therapy Unmet Needs and Analyst Views

Table of Content

1. Introduction
2. Executive Summary
3. TCR Therapy: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Mid Stage Products (Phase II)
7. GSK3377794: GlaxoSmithKline
8. Drug profiles in the detailed report…..
9. Early Stage Products (Phase I/II)
10. BPX-701: Bellicum Pharmaceuticals
11. Drug profiles in the detailed report…..
12. Preclinical stage products
13. MCC1 TCR: Bluebird Bio
14. Drug profiles in the detailed report…..
15. Inactive Products
16. TCR Therapy Key Companies
17. TCR Therapy Key Products
18. TCR Therapy- Unmet Needs
19. TCR Therapy- Market Drivers and Barriers
20. TCR Therapy- Future Perspectives and Conclusion
21. TCR Therapy Analyst Views
22. TCR Therapy Key Companies
23. Appendix

Got Queries? Find out the related information on TCR Therapy Mergers and acquisitions, TCR Therapy Licensing Activities @ TCR Therapy Emerging Drugs, and Recent Trends

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